Which medications in the drug class Estrogen agents are used in the treatment of Hypogonadism?

Updated: Apr 03, 2019
  • Author: Maria G Vogiatzi, MD; Chief Editor: George T Griffing, MD  more...
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Answer

Estrogen agents

These agents are used for sex steroid replacement in females.

Estradiol (Alora, Climara, Esclim, Estrace, FemPatch, Vivelle)

Transdermal: May initiate puberty in girls. Initially, a 0.05-mg patch may be applied 1-2 times/wk. After 6-12 mo, dose may be increased and cycled. After first 6 mo, adding progestogen is often helpful. A very low starting dose of estrogen is desired in young girls with bone ages at or below 12-13 y. Starting at higher doses may cause rapid epiphyseal maturation. If necessary, patches with a matrix-release mechanism (eg, Climara, Vivelle) may be cut to deliver a smaller dose. In the case of the Vivelle dot, half of the dot may be covered in order to lower the amount of estrogen absorbed.

PO: A small unopposed dose (0.02 mg) is administered daily for 3-6 mo, then the dose is increased and cycled. After the first 6 mo, adding progestogen is often helpful.

Conjugated estrogen (Premarin)

May initiate puberty in girls. A small unopposed dose is administered for 3-6 mo, then the dose is increased. After the first 6 mo, adding progestogen is often helpful.


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