How does obesity affect lab study results in men with hypogonadism?

Updated: Apr 03, 2019
  • Author: Maria G Vogiatzi, MD; Chief Editor: George T Griffing, MD  more...
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Answer

Obesity decreases serum SHBG concentrations to a degree that is proportionate to the severity of the obesity, thereby decreasing total testosterone values without usually affecting free testosterone. However, morbid obesity (BMI >40 kg/m2) may be associated with a low free testosterone concentration because of hypothalamic hypogonadism. Decreased SHBG concentrations are also seen in insulin resistance, type II diabetes mellitus, hypothyroidism, glucocorticoid use, and nephrotic syndrome. Increased SHBG concentrations can occur with aging, hyperthyroidism, liver disease, and anticonvulsant use.


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