What are the causes of hypergonadotropic hypogonadism in males?

Updated: Apr 03, 2019
  • Author: Maria G Vogiatzi, MD; Chief Editor: George T Griffing, MD  more...
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Hypergonadotropic hypogonadism in males

Causes include the following:

  • Klinefelter syndrome
  • Inactivating mutations
    • LH beta subunit
    • FSH beta subunit
    • LH receptor
    • FSH receptor
  • Other causes of primary testicular failure
    • Chemotherapy
    • Radiation therapy
    • Gonadectomy
    • Anorchism and cryptorchidism
    • Testicular biosynthetic defects (17β-hydroxylase dehydrogenase deficiency, 5α-reductase deficiency, 17-hydroxylase deficiency)
    • Defects in testicular determination (gonadal dysgenesis)
    • Other rare disorders of sex development (DSDs) (ovotesticular DSD, XX males)
    • Sertoli-cell-only syndrome
    • LH resistance

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