Which toxins have an etiologic role in pediatric hypoglycemia?

Updated: Feb 19, 2018
  • Author: Robert P Hoffman, MD; Chief Editor: Sasigarn A Bowden, MD  more...
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Answer

Hypoglycemia can also be caused by toxins (including ethanol, salicylates, propranolol) and illnesses (eg, malaria). Ethanol inhibits gluconeogenesis in the liver and can thus cause hypoglycemia. (This is particularly true in patients with insulin-treated diabetes who are unable to reduce insulin secretion in response to developing hypoglycemia.) Salicylate intoxication causes hyperglycemia and hypoglycemia. The latter is due to augmentation of insulin secretion and inhibition of gluconeogenesis.


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