Which physical findings are characteristic of Cushing disease in hyperpituitarism?

Updated: Oct 24, 2016
  • Author: Alicia Diaz-Thomas, MD, MPH; Chief Editor: Robert P Hoffman, MD  more...
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Answer

Cushing disease may include the following (see images below):

A 16-year-old boy with Cushing disease. A 16-year-old boy with Cushing disease.
On the left is an unaffected patient aged 12 years On the left is an unaffected patient aged 12 years. On the right is the same patient aged 13 years after developing Cushing disease.

See the list below:

  • Cushingoid appearance includes a dorsal cervical fat pad, moon facies, bruising, and striae. These features are only observed in patients with advanced long-standing disease.

  • Growth failure and short stature may be observed.

  • Weight gain and obesity in children with Cushing disease tends to be generalized rather than centripetal.

  • Pubertal arrest, failure, or delay may occur.

  • Amenorrhea may be noted.

  • Hypertension may be present.


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