Which clinical history findings are characteristic of excess growth hormone in hyperpituitarism?

Updated: Oct 24, 2016
  • Author: Alicia Diaz-Thomas, MD, MPH; Chief Editor: Robert P Hoffman, MD  more...
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Answer

The presentation of gigantism in a child is usually dramatic, unlike the insidious onset of acromegaly in adults.

The cardinal clinical feature of gigantism is longitudinal growth acceleration secondary to GH excess.

Presentation depends on whether the epiphyseal growth plate is open. Before epiphyseal fusion, accelerated growth velocity is prominent. As epiphyseal fusion approaches, the spectrum of symptoms resembles the presentation in adults (eg, coarsening of facial features, change in ring and shoe size).


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