What is the most adverse effect of mineralocorticoid receptor antagonist therapy for idiopathic hyperaldosteronism?

Updated: Oct 19, 2018
  • Author: George P Chrousos, MD, FAAP, MACP, MACE, FRCP(London); Chief Editor: Robert P Hoffman, MD  more...
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Answer

Hyperkalemia is probably considered the most concerning adverse effect of mineralocorticoid receptor antagonist therapy, with a rate of 2-12%. In medically treated patients, it can occur late in therapy, often following years of mineralocorticoid receptor blocker administration, and may require either a decrease in the dose or addition of diuretics. [23]


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