What causes differences in response to spironolactone in the treatment of idiopathic hyperaldosteronism?

Updated: Sep 08, 2020
  • Author: George P Chrousos, MD, FAAP, MACP, MACE, FRCP(London); Chief Editor: Robert P Hoffman, MD  more...
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The difference in response is likely due to pharmacologic differences, as metabolites of spironolactone are biologically active and have relatively long half-lives, whereas eplerenone has a relatively short half-life of approximately 4 hours, and its metabolites are inactive. [26]

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