What are possible complications of adrenal venous sampling (AVS) in the workup of hyperaldosteronism?

Updated: Sep 08, 2020
  • Author: George P Chrousos, MD, FAAP, MACP, MACE, FRCP(London); Chief Editor: Robert P Hoffman, MD  more...
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Adrenal venous sampling is not without risk and can lead to damage of the adrenal gland if not performed correctly. The major complications include adrenal vein rupture, infarction, thrombosis, groin hematoma, and adrenal hemorrhage, whereas associated complete and permanent adrenal insufficiency have been only occasionally reported. Even in experienced centers, the complication rate averages 0.5-2.5%. Similarly, failure to cannulate the right adrenal vein (≤ 20% of cases) can lead to an incorrect diagnosis of unilateral disease when, in fact, both glands are affected.

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