How is Liddle syndrome differentiated from hyperaldosteronism?

Updated: Sep 08, 2020
  • Author: George P Chrousos, MD, FAAP, MACP, MACE, FRCP(London); Chief Editor: Robert P Hoffman, MD  more...
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Liddle syndrome

Liddle syndrome is an autosomal dominant disorder that can partially mimic hyperaldosteronism. Patients present at a young age with hypertension and hypokalemia. Both PRA and aldosterone levels are suppressed. It is caused by mutations of the carboxy terminus of the beta-subunits or gamma-subunits of the renal epithelial sodium channel (ENaC), which result in a constitutively open channel. Treatment with the potassium-sparing diuretic triamterene or amiloride is often effective.

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