What is the Aldosteronoma Resolution Score (ARS) and how is it used in hyperaldosteronism?

Updated: Oct 19, 2018
  • Author: George P Chrousos, MD, FAAP, MACP, MACE, FRCP(London); Chief Editor: Robert P Hoffman, MD  more...
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Answer

The Aldosteronoma Resolution Score (ARS) is currently the most accurate prediction model for complete resolution of hypertension after adrenalectomy, taking into account 4 preoperative clinical parameters: body mass index (BMI) of 25 kg/m2 or higher, female sex, duration of preoperative hypertension 6 years or longer, and number of preoperative antihypertensive medications (≤2). Each parameter receives a score of 1, with the exception of number of preoperative medications, which is scored by 2 points due to its relative significance in the prediction model. A score of 0-1 predicts a low likelihood of resolution, whereas patients with ARS scores of 4-5 have a high likelihood of resolution of hypertension after adrenalectomy.

Moreover, data suggest that the TT genotype of the CYP11B2 gene encoding aldosterone synthase predicts resolution of hypertension in patients undergoing adrenalectomy for aldosterone-producing adenoma.


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