What causes primary hyperaldosteronism?

Updated: Sep 08, 2020
  • Author: George P Chrousos, MD, FAAP, MACP, MACE, FRCP(London); Chief Editor: Robert P Hoffman, MD  more...
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The following is a summary of etiologies of hyperaldosteronism and conditions that mimic hyperaldosteronism:

Causes of primary hyperaldosteronism include the following:

  • APA - High aldosterone, low PRA

  • IHA - Responds to posture (bilateral adrenal hyperplasia)

  • Primary adrenal hyperplasia - Responds to posture (unilateral disease)

  • FH-I (GRA) - Sustained suppression of aldosterone (< 4 ng/dL) with dexamethasone

  • FH-II/FH-III - Familial (probably autosomal dominant)

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