What is the role of microalbuminuria testing in the workup of pediatric type 1 diabetes mellitus (DM)?

Updated: Mar 23, 2021
  • Author: William H Lamb, MD, MBBS, FRCP(Edin), FRCP, FRCPCH; Chief Editor: Sasigarn A Bowden, MD  more...
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Microalbuminuria is the first evidence of nephropathy. The exact definition varies slightly between nations, but an increased AER is commonly defined as a ratio of first morning-void urinary albumin levels to creatinine levels that exceeds 10 mg/mmol, or as a timed, overnight AER of more than 20 mcg/min but less than 200 mcg/min. Early microalbuminuria may resolve. Glomerular hyperfiltration occurs, as do abnormalities of the glomerular basement membrane and glomeruli. Regular urine screening for microalbuminuria provides opportunities for early identification and treatment to prevent renal failure.

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