What is the role of antigliadin antibody testing in the workup of pediatric type 1 diabetes mellitus (DM)?

Updated: Jul 03, 2019
  • Author: William H Lamb, MD, MBBS, FRCP(Edin), FRCP, FRCPCH; Chief Editor: Sasigarn A Bowden, MD  more...
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Answer

Some children with type 1 diabetes mellitus may have or may develop celiac disease. Positive antigliadin antibodies, especially specific antibodies (eg, antiendomysial, antitransglutaminase) are important risk markers. If antibody tests are positive, a jejunal biopsy is required to confirm or refute a diagnosis of celiac disease. Once celiac disease is confirmed, the individual should remain on a gluten-free diet for life.


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