What is the role of islet cell antibody testing in the workup of pediatric type 1 diabetes mellitus (DM)?

Updated: Mar 23, 2021
  • Author: William H Lamb, MD, MBBS, FRCP(Edin), FRCP, FRCPCH; Chief Editor: Sasigarn A Bowden, MD  more...
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Islet cell antibodies may be present at diagnosis but are not needed to diagnose type 1 diabetes mellitus. Islet cell antibodies are nonspecific markers of autoimmune disease of the pancreas and have been found in as many as 5% of unaffected children. Other autoantibody markers of type 1 diabetes are known, including insulin antibodies. Additional antibodies against islet cells are recognized (eg, those against glutamate decarboxylase [GAD antibodies]), but these may not be available for routine testing.

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