How is maturity onset diabetes of the young (MODY) differentiated from pediatric type 1 diabetes mellitus (DM)?

Updated: Jul 03, 2019
  • Author: William H Lamb, MD, MBBS, FRCP(Edin), FRCP, FRCPCH; Chief Editor: Sasigarn A Bowden, MD  more...
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Answer

Children with MODY may present as having type 1 diabetes. As they may respond better to oral hypoglycemic agents, recognizing MODY as a possibility is important. Always consider the diagnosis of MODY in the following circumstances:

  • A strong family history of diabetes across 2 or more generations - The age of diagnosis usually falls with each successive generation

  • Persistently low insulin requirements, particularly with good blood glucose control

  • Development of diabetes from birth or within the first 9 months of life


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