What are the signs and symptoms of combined central diabetes insipidus and cerebral salt- cerebral salt-wasting syndrome (CSWS) (renal salt wasting)?

Updated: May 13, 2020
  • Author: Sudha Garimella, MBBS; Chief Editor: Sasigarn A Bowden, MD  more...
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Answer

A retrospective study by Wu et al found that distinctive features of combined central diabetes insipidus and cerebral salt-wasting syndrome following traumatic brain injury include massive polyuria (the most typical presentation) that responds to vasopressin plus cortisone acetate but not to vasopressin alone, low central venous pressure, a high level of brain natriuretic peptide precursor in the absence of cardiac dysfunction, high 24-hour urine sodium excretion and hypovolemia, and a much greater osmolarity for urine than for serum. [17]


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