What is the mortality and morbidity of cerebral salt-wasting syndrome (CSWS) (renal salt wasting)?

Updated: May 13, 2020
  • Author: Sudha Garimella, MBBS; Chief Editor: Sasigarn A Bowden, MD  more...
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A study by Kalita et al suggested that cerebral salt wasting is the most frequent cause of stroke-related hyponatremia. The study, of 100 patients with stroke, including 47% with ischemic stroke and 53% with intracerebral hemorrhage, found that 43% of the stroke patients had hyponatremia. Of these, 19 (44.2%) had cerebral salt wasting, while 3 (7.0%) had SIADH, 14 (32.6%) had miscellaneous causes of hyponatremia, and 7 (16.3%) had indeterminate causes of the condition. The investigators also found that length of hospital stay independently predicted the development of cerebral salt wasting and hyponatremia. [13]

A study by Misra et al suggested that in patients with tuberculous meningitis, hypovolemia associated with cerebral salt wasting may play a role in the occurrence of stroke. The report included 81 individuals with tuberculous meningitis, 39.5% of whom suffered ischemic stroke; 50% of these stroke patients had cerebral salt wasting. [14]

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