What is the incidence of cerebral salt-wasting syndrome (CSWS) (renal salt wasting)?

Updated: May 13, 2020
  • Author: Sudha Garimella, MBBS; Chief Editor: Sasigarn A Bowden, MD  more...
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Exact incidence data for this disorder are not available. Approximately 60% of children with brain injuries or tumors develop hyponatremia during their hospital course. Some experts suggest that cerebral salt-wasting syndrome (renal salt wasting) is responsible for hyponatremia at least as often as SIADH is, particularly in neurosurgical patients. Other studies indicate that this syndrome explains the development of hyponatremia in no more than 6% of patients with acute brain injuries. [11] A literature review by Leonard et al found the incidence of cerebral salt-wasting syndrome reported in traumatic brain injury to vary between 0.8-34.6%, with the studies determining these incidences differing with respect to the populations evaluated and the definitions used for hyponatremia and cerebral salt wasting. [12] The exact incidence of renal salt-wasting syndrome without cerebral disease is also unknown.

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