Which medications in the drug class Glucocorticoids are used in the treatment of Congenital Adrenal Hyperplasia?

Updated: Oct 06, 2020
  • Author: Thomas A Wilson, MD; Chief Editor: Sasigarn A Bowden, MD  more...
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Answer

Glucocorticoids

The purpose of glucocorticoid therapy in congenital adrenal hyperplasia is (1) to replace the body's requirement for glucocorticoids under normal conditions and during stress and (2) to suppress ACTH secretion, thereby reducing the stimulus for the adrenal glands to overproduce adrenal androgens in virilizing forms of congenital adrenal hyperplasia. Unfortunately, no currently available preparation is able to mimic the diurnal rhythm of physiologic cortisol secretion. Thus, in an attempt to suppress androgen secretion from the adrenal glands in response to early morning rises in ACTH, overtreatment often occurs, resulting in inhibition of linear growth and Cushingoid features. 

Hydrocortisone (Alkindi Sprinkle, Cortef)

Mimics actions of cortisol, which is the primary steroid hormone secreted by adrenal zona fasciculata and reticularis. DOC in children owing to short half-life and decreased potential for growth suppression. Mineralocorticoid effect occurs with large doses.


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