What is the role of sodium chloride solution in the treatment of congenital adrenal hyperplasia (CAH)?

Updated: Oct 06, 2020
  • Author: Thomas A Wilson, MD; Chief Editor: Sasigarn A Bowden, MD  more...
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Answer

In patients with hypotension, 0.9% (isotonic) sodium chloride solution (450 mL/m2 or 20 mL/kg IV) must be rapidly administered over the first hour. This is followed by a continuous IV infusion of 3200 mL/m2/d or 200 mL/kg per 100 cal/d of estimated resting energy expenditure as isotonic or half-isotonic sodium chloride solution to restore intravascular volume. Dextrose must also be provided.


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