What causes hypoglycemia and hypotension in congenital adrenal hyperplasia (CAH)?

Updated: Oct 06, 2020
  • Author: Thomas A Wilson, MD; Chief Editor: Sasigarn A Bowden, MD  more...
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Answer

Hypoglycemia and hypotension may, in part, be due to associated epinephrine synthesis in the adrenal medulla due to cortisol deficiency. Cortisol, perfusing the adrenal medulla from the cortex, normally stimulates phenylethanolamine N -methyltransferase, the last enzyme in epinephrine synthesis.


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