How may congenital adrenal hyperplasia (CAH) affect the brain's structure, and what are the mortality risk factors for CAH?

Updated: Oct 06, 2020
  • Author: Thomas A Wilson, MD; Chief Editor: Sasigarn A Bowden, MD  more...
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A study by Herting et al indicated that medial temporal lobe volumes are smaller in young people with congenital adrenal hyperplasia, with the lateral nucleus of the amygdala, along with the hippocampal subiculum and CA1 subregion, particularly being affected. [11]

Severe forms of congenital adrenal hyperplasia are potentially fatal if unrecognized and untreated because of the severe cortisol and aldosterone deficiencies that result in salt wasting, hyponatremia, hyperkalemia, dehydration, and hypotension.

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