Which factors increase the risks of hospitalization in patients with congenital adrenal hyperplasia (CAH)?

Updated: Oct 06, 2020
  • Author: Thomas A Wilson, MD; Chief Editor: Sasigarn A Bowden, MD  more...
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Answer

A study by Halper et al of 42 children with congenital adrenal hyperplasia reported that total body bone mineral density was lower in these youngsters than in controls (0.81 g/cm2 vs 1.27 g/cm2, respectively). However, no significant differences in body composition, including with regard to visceral adipose tissue and android:gynoid ratio, were found between the two groups. [9]

A study by Yang and White indicated that in children with the salt-wasting form of 21-hydroxylase deficiency congenital adrenal hyperplasia, the risk of postdiagnostic hospitalization is greater in patients younger than 2 years (possibly resulting from a higher susceptibility to viral infections and a lower ability to cope with stress and dehydration) and those who need a greater daily dosage of fludrocortisone (perhaps because these patients are likely to have more severe disease). The study also found that children with noncommercial insurance were more likely to be hospitalized, possibly because they are more likely to experience social barriers to treatment compliance. [10]


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