Which medications in the drug class Mineralocorticoids are used in the treatment of Pediatric Adrenal Insufficiency (Addison Disease)?

Updated: Mar 10, 2020
  • Author: Kimberly Tafuri, DO; Chief Editor: Sasigarn A Bowden, MD  more...
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Mineralocorticoids are used as replacement therapy in aldosterone deficiency and as prophylaxis against hyponatremia and hyperkalemia in patients with primary adrenal insufficiency (Addison disease).


Fludrocortisone is the drug of choice (DOC) for mineralocorticoid replacement therapy if the zona glomerulosa of the adrenal cortex does not produce aldosterone. This agent allows patients to achieve normal sodium homeostasis.

Fludrocortisone is available only in an oral (PO) formulation. If patient cannot tolerate PO, parenteral hydrocortisone can provide a mineralocorticoid effect. Infants may require sodium chloride supplements, because their diets often provide insufficient sodium.

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