What is the role of antiadrenal antibody testing in the workup of pediatric adrenal insufficiency (Addison disease)?

Updated: Dec 07, 2018
  • Author: Kimberly Tafuri, DO; Chief Editor: Sasigarn A Bowden, MD  more...
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Answer

When primary adrenal insufficiency (Addison disease) is confirmed, antiadrenal antibodies, specifically anti-21-hydroxylase antibodies, can confirm an autoimmune cause for the disorder. If results for antiadrenal antibodies are negative, search for another etiology, such as tuberculosis (TB), adrenal hemorrhage, or adrenoleukodystrophy.


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