Which medications in the drug class Antidepressants, TCAs are used in the treatment of Pediatric Sleep Disorders?

Updated: Oct 09, 2018
  • Author: Sufen Chiu, MD, PhD; Chief Editor: Caroly Pataki, MD  more...
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Antidepressants, TCAs

Tricyclic antidepressants are used for treating narcolepsy and enuresis. Scant data exist to support their use in childhood narcolepsy. Sudden death has been reported in 8 children, possibly related to use of imipramine and desipramine; findings have been inconclusive about the causes of these deaths. No FDA indication exists for use of these agents in children with narcolepsy and enuresis.

Imipramine (Tofranil, Tofranil PM)

Imipramine inhibits the reuptake of norepinephrine or serotonin (5-hydroxytryptamine, 5-HT) at the presynaptic neuron. It may be useful for treating pediatric attention deficit hyperactivity disorder (ADHD), as well as enuresis and, possibly, pediatric-onset narcolepsy.

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