Which medications in the drug class Melatonin Receptor Agonists are used in the treatment of Pediatric Sleep Disorders?

Updated: Oct 09, 2018
  • Author: Sufen Chiu, MD, PhD; Chief Editor: Caroly Pataki, MD  more...
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Answer

Melatonin Receptor Agonists

In patients with circadian rhythm disorders, melatonin agonists may be used. Melatonin acts directly on suprachiasmatic nuclei. Use of OTC melatonin in children is recommended to be brief and not to exceed 10 mg per day. [26]

Melatonin

Melatonin is used to treat circadian rhythm disturbances in blind patients without light perception. Use in children is recommended to be brief and not to exceed 10 mg per day. The dose of melatonin will vary depending on the formulation. Over-the-counter forms of melatonin vary in quality and reliability.

Ramelteon (Rozerem)

Ramelteon is a melatonin receptor agonist with high selectivity for human melatonin MT1 and MT2 receptors. MT1 and MT2 are thought to promote sleep and to be involved in maintaining circadian rhythm and normal sleep-wake cycles. Ramelteon is indicated for insomnia in adults characterized by difficulty with sleep onset.


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