Which medications in the drug class Nonbenzodiazepine Hypnotics are used in the treatment of Pediatric Sleep Disorders?

Updated: Oct 09, 2018
  • Author: Sufen Chiu, MD, PhD; Chief Editor: Caroly Pataki, MD  more...
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Answer

Nonbenzodiazepine Hypnotics

Studies of the use of sedative-hypnotics to treat sleep disorders are limited to adults, and no FDA indications are approved for children younger than 18 years.

Eszopiclone (Lunesta)

Eszopiclone is a nonbenzodiazepine hypnotic pyrrolopyrazine derivative of the cyclopyrrolone class. The precise mechanism of action is unknown but is believed to involve interaction with gamma-aminobutyric acid (GABA) receptors at binding domains close to, or allosterically coupled to, benzodiazepine receptors.

Eszopiclone is indicated for treatment of insomnia in adults by decreasing sleep latency and improving sleep maintenance. It has a short half-life (6 hours). Higher doses (ie, 2 mg for elderly and 3 mg for nonelderly adults) are more effective for sleep maintenance, whereas lower doses (ie, 1 mg for elderly and 2 mg for nonelderly adults) are suitable for treating difficulty in falling asleep.


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