Which medications in the drug class Central alpha-2 agonist are used in the treatment of Pediatric Sleep Disorders?

Updated: Oct 09, 2018
  • Author: Sufen Chiu, MD, PhD; Chief Editor: Caroly Pataki, MD  more...
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Central alpha-2 agonist


Antihypertensive used for many decades to treat insomnia in children. Now it is currently approved in extended release form for the treatment of Attention Deficit Hyperactivity Disorder. The benefit of sedation wears off in several weeks but may have continued benefit for reducing nightmares associated with trauma (insert new reference Belkin MR, Schwartz TL. Drugs in Context 2015; 4: 212286. DOI: 10.7573/dic.212286 1 of 5 ISSN: 1740-4398). Main side effects are sedation and dizziness. Duration of effect is usually 2 to 4 hours so may result in nighttime awakening unless extended release is prescribed

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