Which medications in the drug class Antipsychotics are used in the treatment of Borderline Personality Disorder?

Updated: Nov 05, 2018
  • Author: Roy H Lubit, MD, PhD; Chief Editor: Caroly Pataki, MD  more...
  • Print
Answer

Antipsychotics

Low-dose neuroleptics are effective in the short term for control of transient psychotic symptoms. Antipsychotics have long been used to control impulsivity and aggression in patients with BPD, although SSRIs are preferred because of their more benign adverse effect profile.

Low-dose neuroleptics are effective in the short term for control of transient psychotic symptoms. Antipsychotics have long been used to control impulsivity and aggression in patients with BPD, although SSRIs are preferred because of their more benign adverse effect profile.

Risperidone (Risperdal)

Risperidone binds to dopamine D2 receptors with an affinity 20 times lower than its affinity for the serotonin 5-HT2 receptor. It improves negative symptoms of psychoses and reduces the incidence of extrapyramidal adverse effects. Risperidone is FDA-approved for several indications in pediatric patients: schizophrenia in adolescents (13-17 years), bipolar mania in children and adolescents (10-17 years), and irritability associated with autistic disorder in children (5-16 years). It is available as an oral solution.

Olanzapine (Zyprexa)

Olanzapine may inhibit the effects of serotonin, muscarine, and dopamine.

Quetiapine (Seroquel)

Quetiapine may act by antagonizing the effects of dopamine and serotonin. Its efficacy is similar to that of risperidone and olanzapine. This agent causes fewer dose-dependent adverse effects and less concern regarding weight gain.


Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!