What is the pathophysiology of borderline personality disorder (BPD)?

Updated: Nov 05, 2018
  • Author: Roy H Lubit, MD, PhD; Chief Editor: Caroly Pataki, MD  more...
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Some studies have suggested that patients with BPD might have increased rates of soft neurologic signs, [12] as well as learning disorders, attention-deficit/hyperactivity disorder (ADHD), and abnormal electroencephalographic (EEG) findings. [13] Reports also indicate that adults with BPD have increased impulsivity, cognitive inflexibility, and poor self-monitoring and perseveration, which may be indicators of frontal lobe dysfunction.

The pathogenesis of BPD, like those of most psychiatric disorders, is likely to include an organic predisposition as well as psychosocial and environmental factors. Some researchers postulate the presence of an underlying affective instability to which the individual responds with maladaptive behaviors.

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