Which medications in the drug class Benzodiazepines are used in the treatment of Avoidant Personality Disorder?

Updated: Nov 12, 2019
  • Author: David C Rettew, MD; Chief Editor: Caroly Pataki, MD  more...
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Answer

Benzodiazepines

These agents bind to a specific benzodiazepine receptor on the gamma-aminobutyric acid (GABA) receptor complex, thereby increasing GABA affinity for its receptor. They also increase the frequency of chlorine channel opening in response to GABA binding. GABA receptors are chlorine channels that mediate postsynaptic inhibition, resulting in postsynaptic neuron hyperpolarization. The final result is a sedative-hypnotic and anxiolytic effect. High-potency benzodiazepines are likely to be effective in treating social phobia in adults.

Clonazepam (Klonopin)

Used clinically to treat social anxiety, although no controlled studies have been conducted in this population to document its efficacy. This medication is believed to work at the GABAa receptor in the brain, particularly the limbic areas.


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