How prevalent is autism spectrum disorder (ASD) among siblings?

Updated: Sep 30, 2019
  • Author: James Robert Brasic, MD, MPH; Chief Editor: Caroly Pataki, MD  more...
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Siblings of children with autism are at risk for developing traits of autism and even a full-blown diagnosis of autism. A tenth of the siblings of children with autism meet the diagnostic criteria for an autism spectrum disorder. An additional fifth of siblings of children with autism have delayed development of language. [54] Screening should be performed not only for autism-related symptoms but also for language delays, learning difficulties, social problems, and anxiety or depressive symptoms. [2]  The American College of Medical Genetics and Genomics identified the risks of a siblings developing ASD as 4% if the proband is male, 7% if the proband is female, and greater than or equal to 30% if there are two or more affected children. [123]

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