Which patient groups have the highest prevalence of autism spectrum disorder (ASD)?

Updated: Sep 30, 2019
  • Author: James Robert Brasic, MD, MPH; Chief Editor: Caroly Pataki, MD  more...
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Answer

Estimates of the prevalence of ASD vary widely by sex. Combining data from all 11 Autism and Developmental Disabilities Monitoring (ADDM) Network communities, ASD prevalence prevalence was 26.6 per 1,000 boys and 6.6 per 1,000 girls (prevalence ratio: 4.0). ASD prevalence was significantly (p< 0.01) higher among boys than among girls in all 11 ADDM sites, with male-to-female prevalence ratios ranging from 3.2 (Arizona) to 4.9 (Georgia). [96]

Autistic disorder is most common in boys who have the 46,XY karyotype (ie, the normal male karyotype). In some studies, fragile X is reported in approximately 10% males with autistic disorder. [102, 103, 104, 105, 106, 107]


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