What is the role of parental age in the etiology of autism spectrum disorder (ASD)?

Updated: Sep 30, 2019
  • Author: James Robert Brasic, MD, MPH; Chief Editor: Caroly Pataki, MD  more...
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Answer

Meta-analyses of epidemiologic studies have shown that autism risk in offspring increases when the age of either parent is 35 years or higher. [55] Sandin et al reported that, after controlling for paternal age, the adjusted relative risk for autism was 1.52 in the offspring of mothers aged 35 years or older compared with mothers aged 25–29 years. [83] Hultman et al found that, after controlling for maternal age, offspring of men aged 50 years or older were 2.2 times more likely to have autism than offspring of men aged 29 years or younger. [84]


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