Which medications in the drug class Protective topical agents are used in the treatment of Diaper Dermatitis (Diaper Rash)?

Updated: Oct 16, 2020
  • Author: Ruchir Agrawal, MD; Chief Editor: Dirk M Elston, MD  more...
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Protective topical agents

Ideally, first-line therapy for diaper dermatitis is zinc oxide ointment. The safest over-the-counter (OTC) emollient available for newborns is pure white petrolatum ointment. Another safe alternative is Aquaphor ointment, which is principally composed of white petrolatum, mineral oil, and lanolin. It is more expensive than pure white petrolatum ointment. Petrolatum, zinc oxide, aluminum acetate solution (1-2-3 Paste) is a combination product and is both a skin protectant and has a drying effect on vesicular or wet dermatoses.

Petrolatum topical (Aveeno Skin Relief Healing Ointment, Neosporin Lip Health Overnight Renewal Therapy)

Petrolatum traps water beneath the epidermis.

Zinc oxide topical (Aveeno Baby Organic Harvest Diaper Rash Cream, Desitin, Desitin Creamy)

Zinc oxide has antiseptic and astringent properties. It plays a significant role in wound healing with low risk for allergic or contact dermatitis. To remove zinc oxide from the skin, mineral oil is more effective and easier than soap and water.

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