How effective are monoclonal antibodies for the treatment of pediatric atopic dermatitis (AD)?

Updated: Jun 03, 2020
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Dirk M Elston, MD  more...
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Answer

Dupilumab, a monoclonal antibody targeting the α-subunit of the IL-4 receptor to produce inhibition of both the IL-4 and IL-13 pathways, is of value in moderate-to-severe atopic dermatitis. [59, 64]  Lebrikizumab, an investigational anti–IL-13 monoclonal antibody, may prove of value in children as an add-on to topical corticosteroid therapy. [67]


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