Which drugs may be effective for treatment of molluscum contagiosum?

Updated: Sep 21, 2020
  • Author: Ashish C Bhatia, MD, FAAD, FACMS; Chief Editor: Dirk M Elston, MD  more...
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Topical podophyllotoxin 0.5% cream self-administered twice daily for 3 weeks has been reported effective in a placebo-controlled, double-blind study. [38] Dilute povidone iodine has also been used. [39]

Reports have suggested that subcutaneous interferon-alfa administered intralesionally may be useful in immunocompromised children.

A case report noted the efficacy of topical cidofovir in the treatment of disseminated molluscum in immunodepressed patients. [5] Cidofovir diphosphate was reported to inhibit molluscum contagiosum virus DNA polymerase activity. [40]

Imiquimod cream is an immune response modifier approved for the treatment of external genital and perianal warts in adults. In the past, it was used in molluscum contagiosum; however, imiquimod cream has been reported to be ineffective in the treatment of molluscum contagiosum, [30, 31, 32, 33] particularly in children, in whom adverse effects have been noted. [32]

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