Which drugs may be effective for treatment of molluscum contagiosum?

Updated: Aug 09, 2018
  • Author: Ashish C Bhatia, MD, FAAD, FACMS; Chief Editor: Dirk M Elston, MD  more...
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Answer

Topical podophyllotoxin 0.5% cream self-administered twice daily for 3 weeks has been reported effective in a placebo-controlled, double-blind study. [36] Dilute povidone iodine has also been used. [37]

Reports have suggested that subcutaneous interferon-alfa administered intralesionally may be useful in immunocompromised children.

A case report noted the efficacy of topical cidofovir in the treatment of disseminated molluscum in immunodepressed patients. [5] Cidofovir diphosphate was reported to inhibit molluscum contagiosum virus DNA polymerase activity. [38]

Imiquimod cream is an immune response modifier approved for the treatment of external genital and perianal warts in adults. In the past, it was used in molluscum contagiosum; however, imiquimod cream has been reported to be ineffective in the treatment of molluscum contagiosum, [28, 29, 30, 31] particularly in children, in whom adverse effects have been noted. [30]


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