Which comorbidities are associated with disfiguring molluscum contagiosum lesions?

Updated: Aug 09, 2018
  • Author: Ashish C Bhatia, MD, FAAD, FACMS; Chief Editor: Dirk M Elston, MD  more...
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Disfiguring lesions may occur in patients with the following conditions:

  • AIDS: Facial and perioral molluscum contagiosum are most commonly observed as a manifestation of HIV infection, particularly in homosexual men with HIV [19] ; at the time of molluscum contagiosum diagnosis, the CD4 count is low.

  • Immunocompromise: Lesions are especially common and extensive on the face and neck.

  • Lymphocytic leukemia

  • Congenital immunodeficiency

  • Selective immunoglobulin M (IgM) deficiency

  • Thymoma

  • Treatment with prednisone and methotrexate

  • Disseminated malignancy

  • Refractory atopic dermatitis

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