Which medications in the drug class Antihistamines are used in the treatment of Pediatric Aphthous Ulcers?

Updated: Feb 25, 2019
  • Author: Michael C Plewa, MD; Chief Editor: Russell W Steele, MD  more...
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These drugs act by competitively inhibiting histamine at the H1 receptor. They prevent histamine responses in sensory nerve endings to relieve symptoms (eg, localized irritation, pain).

Diphenhydramine elixir (Benadryl)

First-line antihistamine for topical treatment of localized skin and mucus-membrane irritation. May be applied directly to ulcerated submucosal tissue. Relieves PO pain in some patients.

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