Which medications in the drug class Topical corticosteroids are used in the treatment of Pediatric Aphthous Ulcers?

Updated: Feb 25, 2019
  • Author: Michael C Plewa, MD; Chief Editor: Russell W Steele, MD  more...
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Answer

Topical corticosteroids

These drugs decrease inflammation by suppressing migration of polymorphonuclear (PMN) leukocytes and reversing capillary permeability. Many factors, including the vehicle, the integrity of the mucosal barrier, the amount of friction from adjacent structures, and the amount of salivation determine the extent of mucocutaneous absorption. The medical profile for triamcinolone is outlined below; other medications with the same or similar profiles include betamethasone valerate 0.1% (Valisone), clobetasol propionate 0.05% cream or ointment (Temovate), dexamethasone (Decadron), halobetasol propionate 0.05% ointment (Ultravate), and fluocinonide 0.05% gel (Lidex).

A benzocaine preparation (Orabase B) is sometimes added to the corticosteroid, but the practice remains controversial. Data suggest that the benzocaine preparation helps keep the steroid in prolonged contact with the mucosal surface; however, its addition dilutes the mixture, lessening steroid potency. To add the benzocaine preparation to any of these topical steroid prescriptions, simply mix the steroid preparation 1:1 with Orabase.

Triamcinolone topical (Kenalog in Orabase, Oralone Dental)

Moderate-potency steroid; reduces pain and inflammation at ulcer sites. Close follow-up required to monitor for candidiasis and other secondary infections and adverse effects. Available as dental paste 0.1%.


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