What is the role of dietary modifications in the treatment of pediatric aphthous ulcers?

Updated: Feb 25, 2019
  • Author: Michael C Plewa, MD; Chief Editor: Russell W Steele, MD  more...
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  • Supplementation with vitamins (especially B12 and C), [79, 80, 81, 82] zinc, or iron may prevent recurrence in some individuals. Studies of lysine supplementation are preliminary and equivocal. [83]  A randomized, double-blind study on 42 patients reported data showing that vitamin B12 can be an effective analgesic treatment for aphthous ulcers. [84]

  • A gluten-free diet is unlikely to improve recurrent aphthous ulcers (canker sores) unless the patient has celiac disease (gluten-sensitive enteropathy), which may be present in as many as 5% of patients in whom recurrent aphthous ulcers (canker sores) are initially diagnosed.

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