What is the role of metalloproteinase inhibitors in the treatment of pediatric aphthous ulcers?

Updated: Feb 25, 2019
  • Author: Michael C Plewa, MD; Chief Editor: Russell W Steele, MD  more...
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Metalloproteinase inhibitors include tetracycline, doxycycline and minocycline. These agents, such as doxycycline in a hydrogel or minocycline 0.2% oral rinse solution, [43] demonstrate significant improvement in ulcer healing as well as pain reduction, all at low doses without likelihood of systemic effects or alteration in oral flora. [44, 45, 43] This class of agents should not be used in women who are pregnant or in children.

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