How quickly do infants respond to inhaled nitric oxide (iNO) for treatment of persistent pulmonary hypertension of the newborn (PPHN)?

Updated: Sep 03, 2019
  • Author: Kate A Tauber, MD; Chief Editor: Howard S Weber, MD, FSCAI  more...
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Answer

Answer

In infants who respond, an improvement in oxygenation is evident within few minutes. Some studies have shown that concentrations as low as 5 ppm are effective in improving oxygenation. [43, 44] Lower concentrations (2 ppm) are not effective. [45] Once initiated, iNO should be gradually weaned to prevent rebound vasoconstriction.


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