What is the role of drug treatment for persistent pulmonary hypertension of the newborn (PPHN)?

Updated: Sep 03, 2019
  • Author: Kate A Tauber, MD; Chief Editor: Howard S Weber, MD, FSCAI  more...
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Answer

Answer

In addition to oxygen supplementation, therapeutic strategies to manage persistent pulmonary hypertension of the newborn (PPHN) include lung recruitment with optimal mean airway pressure, surfactant (especially if meconium aspiration syndrome or respiratory distress syndrome is suspected), and the use of inhaled and intravenous vasodilators. Sedation with morphine along with a benzodiazepine is often necessary to prevent any agitation, which may worsen the PPHN.


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