What is the role of paralytic agents in the treatment of persistent pulmonary hypertension of the newborn (PPHN)?

Updated: Sep 03, 2019
  • Author: Kate A Tauber, MD; Chief Editor: Howard S Weber, MD, FSCAI  more...
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Answer

Answer

The use of paralytic agents is highly controversial and is typically reserved for newborns who cannot be treated with sedatives alone. Be aware that paralysis, in particular with pancuronium, may promote atelectasis of dependent lung regions and promote ventilation-perfusion mismatch.

A review of 385 newborns with persistent pulmonary hypertension of the newborn by Walsh-Sukys et al suggested that paralysis may be associated with an increased risk of death. [39]


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