What causes hypoplasia of the pulmonary vascular bed in persistent pulmonary hypertension of the newborn (PPHN)?

Updated: Sep 03, 2019
  • Author: Kate A Tauber, MD; Chief Editor: Howard S Weber, MD, FSCAI  more...
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Answer

Answer

Hypoplasia of the pulmonary vascular bed is another cause of persistent pulmonary hypertension of the newborn.

Congenital diaphragmatic hernia is an abnormality of diaphragmatic development that allows the abdominal viscera to enter the chest and compress the lung, impairing growth.

Oligohydramnios may also produce pulmonary hypoplasia and associated persistent pulmonary hypertension of the newborn.

A congenital cystic adenomatoid malformation may lead to lung hypoplasia, but PPHN is not a common finding in this condition. [22]


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