What are the most common causes of persistent pulmonary hypertension of the newborn (PPHN)?

Updated: Sep 03, 2019
  • Author: Kate A Tauber, MD; Chief Editor: Howard S Weber, MD, FSCAI  more...
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Persisten pulmonary hypertension of the newborn (PPHN) is most commonly associated with 1 of 3 underlying etiologies [20] :

  • Acute pulmonary vasoconstriction

  • Hypoplasia of the pulmonary vascular bed (commonly seen with congenital diaphragmatic hernia)

  • Idiopathic pulmonary hypertension

There also appears to be a complex relationship between PPHN and cesarean delivery, including the following factors [21] :

  • Iatrogenic prematurity

  • Higher rates of late preterm delivery

  • Lack of physiologic changes of labor

  • Limited pulmonary vasodilator synthesis

  • Lower levels of protective antioxidants

  • Greater risk of respiratory distress syndrome, with a concomitant rise in endothelin-1 levels

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