What are symptoms of severe persistent pulmonary hypertension of the newborn (PPHN)?

Updated: Sep 03, 2019
  • Author: Kate A Tauber, MD; Chief Editor: Howard S Weber, MD, FSCAI  more...
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In some newborns, this normal decrease in pulmonary vascular tone does not occur, resulting in PPHN. This results in shunting of blood away from the lungs and severe central hypoxemia.

Severe PPHN can be associated with poor cardiac output and shock, signs of which include tachycardia, ashen or gray color, capillary refill time more than 3 seconds, oliguria, hypotension, and lactic acidosis. This is commonly seen when the ductus arteriosus is restrictive and right-to-left shunting is compromised at this level or at the foramen ovale.

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